Best Anxiety Supplements of 2025
Evidence-based reviews and comparisons to help you find natural relief from anxiety symptoms.
Medically Reviewed
By our team of mental health specialists
Finding the Right Anxiety Supplement
Anxiety affects millions of people worldwide, causing significant distress and impairment in daily life. Anxiety supplements can play a valuable role in supporting mental health and reducing symptoms.
Our comprehensive guide examines the most effective anxiety supplements available in 2025, analyzing their ingredients, potency, scientific backing, and value. We've spent over 300 hours researching and testing these products to provide you with accurate, unbiased information to make an informed decision.
How We Evaluate Anxiety Supplements
Each supplement is evaluated based on ingredient quality, clinical research, effective dosages, manufacturing standards, and customer feedback. Our ratings consider effectiveness, value, and safety to provide a comprehensive assessment.
Top-Rated Anxiety Supplements of 2025
Our experts have analyzed dozens of anxiety supplements based on natural ingredients, clinical evidence, effectiveness, and user experiences.
Ashwagandha 1300mg with
NutriRise
A high-quality supplement for anxiety relief and stress management.
Key Ingredients:
- • Ashwagandha
- • Black Pepper Extract
L-Theanine 200mg Supplement
Sports Research
A high-quality supplement for anxiety relief and stress management.
Key Ingredients:
- • L-Theanine
- • Coconut Oil
Magnesium Glycinate 400mg
Doctor's Best
A high-quality supplement for anxiety relief and stress management.
Key Ingredients:
- • Magnesium Glycinate
- • Magnesium Lysinate Chelate
Top-Rated Anxiety Supplements on Amazon
The most popular and highly-rated anxiety supplements available on Amazon.
Ashwagandha 1300mg with Black Pepper Extract
NutriRise
Key Ingredients:
- Ashwagandha
- Black Pepper Extract
Benefits:
- Stress relief
- Mood support
L-Theanine 200mg Supplement for Stress Relief
Sports Research
Key Ingredients:
- L-Theanine
- Coconut Oil
Benefits:
- Promotes relaxation without drowsiness
- Supports stress management
Magnesium Glycinate 400mg - 240 Capsules
Doctor's Best
Key Ingredients:
- Magnesium Glycinate
- Magnesium Lysinate Chelate
Benefits:
- Promotes relaxation
- Supports healthy stress response
Natural Vitality Calm Magnesium Supplement
Natural Vitality
Key Ingredients:
- Magnesium Citrate
Benefits:
- Stress relief
- Promotes relaxation
Organic Ashwagandha Root Powder with Black Pepper Extract
Organic India
Key Ingredients:
- Organic Ashwagandha Root
- Black Pepper Extract
Benefits:
- Stress reduction
- Mood enhancement
Anxiety Relief Supplement with 5-HTP and Ashwagandha
Nested Naturals
Key Ingredients:
- 5-HTP
- Ashwagandha
- L-Theanine
Benefits:
- Promotes calmness
- Supports positive mood
Anxiety Supplement Comparison
Compare the top anxiety supplements side-by-side to find the best option for your needs.
| Product | Key Ingredients | Benefits | Rating | Price | Action |
|---|---|---|---|---|---|
Ashwagandha 1300mg with NutriRise | Ashwagandha, Black Pepper Extract | Stress relief, Mood support... | 4.5 ★★★★★ 37,461 reviews | $19.99$29.99 | View on AmazonRead Review |
L-Theanine 200mg Supplement Sports Research | L-Theanine, Coconut Oil | Promotes relaxation without drowsiness, Supports stress management... | 4.6 ★★★★★ 12,776 reviews | $24.95 | View on AmazonRead Review |
Magnesium Glycinate 400mg Doctor's Best | Magnesium Glycinate, Magnesium Lysinate Chelate | Promotes relaxation, Supports healthy stress response... | 4.7 ★★★★★ 18,347 reviews | $29.99 | View on AmazonRead Review |
Natural Vitality Calm Natural Vitality | Magnesium Citrate | Stress relief, Promotes relaxation... | 4.6 ★★★★★ 45,891 reviews | $35.99$39.95 | View on AmazonRead Review |
Anxiety Supplement Ingredients Guide
Learn about the key ingredients found in anxiety supplements and their benefits.
Ashwagandha
300-600mg daily of extract standardized to contain 5-10% withanolides
Ashwagandha (Withania somnifera) is an adaptogenic herb that has been used for thousands of years in Ayurvedic medicine. It helps the body adapt to stress and promotes balance in various bodily systems. Research suggests it works by modulating stress pathways in the brain and reducing cortisol levels.
Key Benefits:
- Reduces stress and anxiety
- Lowers cortisol levels
- Improves sleep quality
- Enhances resilience to stress
Scientific Research:
An investigation into the stress-relieving and pharmacological actions of an ashwagandha extract (2019)
A randomized, double-blind, placebo-controlled trial found that ashwagandha extract significantly reduced stress and cortisol levels compared to placebo.
View StudyEfficacy and Safety of Ashwagandha Root Extract in Insomnia and Anxiety (2019)
A study found that ashwagandha root extract improved sleep quality and reduced anxiety in participants with insomnia and anxiety.
View StudyA Randomized, Double-Blind, Placebo-Controlled, Clinical Study on the Effects of Ashwagandha on Stress and Anxiety (2012)
Research showed that participants taking ashwagandha had significantly lower scores on stress assessment scales and lower serum cortisol levels compared to those taking placebo.
View StudyScientific Research on Anxiety Supplements
An overview of the current scientific understanding of anxiety supplement ingredients.
Evidence-Based Anxiety Supplements
Several natural supplements have shown promise in scientific research for reducing anxiety symptoms. Here's what the latest studies tell us:
Ashwagandha
Multiple randomized controlled trials have found that ashwagandha significantly reduces anxiety and stress. A 2019 double-blind study published in Medicine (Baltimore) found that participants taking ashwagandha extract experienced a 44% reduction in stress levels compared to just 5.5% in the placebo group. The supplement appears to work by reducing cortisol levels and modulating stress response pathways in the brain.
L-Theanine
This amino acid found in tea leaves has been shown to increase alpha brain wave activity, which is associated with a state of relaxed alertness. A 2019 study in Nutrients found that L-theanine reduced stress-related symptoms and improved cognitive function in healthy adults under stress conditions. It appears to work by affecting neurotransmitters like GABA, serotonin, and dopamine.
Magnesium
A 2017 systematic review published in Nutrients found that magnesium supplementation may have a beneficial effect on subjective anxiety and stress in vulnerable populations. Magnesium plays a crucial role in regulating neurotransmitters involved in stress response and anxiety. Magnesium glycinate and threonate forms appear to be particularly effective for anxiety due to their bioavailability and ability to cross the blood-brain barrier.
Research Quality Considerations
While promising, much of the research on natural anxiety supplements involves relatively small sample sizes and varying methodologies. More large-scale, long-term studies are needed to fully establish efficacy and optimal dosing protocols. Always consult with a healthcare provider before starting any supplement regimen, especially if you have existing health conditions or take medications.
Frequently Asked Questions
Get answers to common questions about anxiety supplements.
Ready to Support Your Mental Health?
Browse our top-rated anxiety supplements and find the right option for your needs.
Disclaimer
The information provided on this page is intended for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider before starting any supplement regimen, especially if you have existing health conditions or are taking medications.
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Last updated: February 2025