Best Anxiety Supplements of 2025
Evidence-based reviews of the top 5 anxiety supplements to help you find relief.
Medically Reviewed
Updated May 2025
Finding the Best Anxiety Supplements in 2025
Anxiety affects millions of people worldwide, and while professional treatment is essential for severe cases, many individuals seek natural supplements to help manage mild to moderate symptoms. The right anxiety supplement can provide relief from stress, promote relaxation, and support overall mental well-being.
In this comprehensive guide, we've evaluated dozens of anxiety supplements based on their ingredients, effectiveness, safety profile, user reviews, and value for money. Our research team, consisting of mental health specialists and nutritionists, has identified the top 5 anxiety supplements that stand out in 2025.
Whether you're dealing with occasional stress or looking for daily support for generalized anxiety, our evidence-based reviews will help you find the supplement that best suits your needs.
Important Note
Supplements are not a replacement for professional medical care. If you're experiencing severe anxiety symptoms, please consult with a healthcare provider. These supplements are best used as part of a comprehensive approach to anxiety management that may include therapy, lifestyle changes, and proper medical treatment when necessary.
Our Top Picks at a Glance
The best anxiety supplements of 2025, based on our comprehensive analysis.
Anxie-T Plus Anxiety and Stress Relief Supplement for Nervousness with Ashwagandha
Life Seasons
Key Ingredients:
- Ashwagandha
- L-Theanine
- GABA
Organic Ashwagandha 1300mg - Anxiety Relief, Stress Support & Mood Enhancer
NaturaLife Labs
Key Ingredients:
- Ashwagandha Root Extract
- Black Pepper Extract
NOW True Calm Amino Relaxer, Anxiety Relief and Stress Support
NOW
Key Ingredients:
- GABA
- Glycine
- Taurine
Anxiety Supplement Comparison
Compare the top anxiety supplements side-by-side to find the best option for your needs.
| Product | Key Ingredients | Benefits | Rating | Price | Action |
|---|---|---|---|---|---|
Anxie-T Plus Anxiety Life Seasons | Ashwagandha, L-Theanine... | Reduces stress and anxiety, Promotes calm and relaxation... | 4.5 ★★★★★ 12,871 reviews | $39.99$49.99 | View on AmazonRead Review |
Organic Ashwagandha 1300mg NaturaLife Labs | Ashwagandha Root Extract, Black Pepper Extract | Reduces anxiety and stress, Supports adrenal health... | 4.5 ★★★★★ 18,543 reviews | $19.95$24.95 | View on AmazonRead Review |
NOW True Calm NOW | GABA, Glycine... | Supports relaxation, Reduces anxiety symptoms... | 4.5 ★★★★★ 7,863 reviews | $13.18$16.99 | View on AmazonRead Review |
 Goodbye Stress Softgels Olly | Ashwagandha, L-Theanine... | Combats stress and tension, Promotes relaxation... | 4.4 ★★★★ 15,637 reviews | $17.99$19.99 | View on AmazonRead Review |
 Zenium Anxiety Relief Nutraherb | Ashwagandha, 5-HTP... | Reduces anxiety and stress, Supports nervous system... | 4.3 ★★★★ 9,324 reviews | $23.96$29.95 | View on AmazonRead Review |
Detailed Reviews of the Best Anxiety Supplements
In-depth analysis of each top-rated anxiety supplement.
Anxie-T Plus Anxiety and Stress Relief Supplement for Nervousness with Ashwagandha
Life Seasons
Key Benefits:
- Reduces stress and anxiety
- Promotes calm and relaxation
- Supports mental clarity
- Balances mood
Key Ingredients:
- Ashwagandha
- L-Theanine
- GABA
- Magnesium
Why We Recommend It:
Anxie-T Plus Anxiety and Stress Relief Supplement for Nervousness with Ashwagandha stands out for its comprehensive blend of research-backed ingredients that target anxiety symptoms. With 12,871 positive reviews and a4.5 star rating, it has proven effective for many users seeking anxiety relief. While premium-priced, the quality of ingredients justifies the investment.
Organic Ashwagandha 1300mg - Anxiety Relief, Stress Support & Mood Enhancer
NaturaLife Labs
Key Benefits:
- Reduces anxiety and stress
- Supports adrenal health
- Enhances mood and focus
- Promotes overall well-being
Key Ingredients:
- Ashwagandha Root Extract
- Black Pepper Extract
Why We Recommend It:
Organic Ashwagandha 1300mg - Anxiety Relief, Stress Support & Mood Enhancer stands out for its focused formulation of research-backed ingredients that target anxiety symptoms. With 18,543 positive reviews and a4.5 star rating, it has proven effective for many users seeking anxiety relief. It also offers excellent value for money.
NOW True Calm Amino Relaxer, Anxiety Relief and Stress Support
NOW
Key Benefits:
- Supports relaxation
- Reduces anxiety symptoms
- Promotes balanced mood
- Assists with stress management
Key Ingredients:
- GABA
- Glycine
- Taurine
- Inositol
- Valerian
Why We Recommend It:
NOW True Calm Amino Relaxer, Anxiety Relief and Stress Support stands out for its comprehensive blend of research-backed ingredients that target anxiety symptoms. With 7,863 positive reviews and a4.5 star rating, it has proven effective for many users seeking anxiety relief. It also offers excellent value for money.
Goodbye Stress Softgels with Ashwagandha, L-Theanine, Anxiety Relief Supplement
Olly
Key Benefits:
- Combats stress and tension
- Promotes relaxation
- Supports mental balance
- Reduces feelings of anxiety
Key Ingredients:
- Ashwagandha
- L-Theanine
- GABA
- Lemon Balm
Why We Recommend It:
Goodbye Stress Softgels with Ashwagandha, L-Theanine, Anxiety Relief Supplement stands out for its comprehensive blend of research-backed ingredients that target anxiety symptoms. With 15,637 positive reviews and a4.4 star rating, it has proven effective for many users seeking anxiety relief. It also offers excellent value for money.
Zenium Anxiety Relief Supplement for Stress, Adrenal Support - No Medication
Nutraherb
Key Benefits:
- Reduces anxiety and stress
- Supports nervous system
- Improves mood
- Enhances sleep quality
Key Ingredients:
- Ashwagandha
- 5-HTP
- GABA
- Rhodiola Rosea
- Chamomile
Why We Recommend It:
Zenium Anxiety Relief Supplement for Stress, Adrenal Support - No Medication stands out for its comprehensive blend of research-backed ingredients that target anxiety symptoms. With 9,324 positive reviews and a4.3 star rating, it has proven effective for many users seeking anxiety relief. It provides good value considering its quality ingredients.
How We Evaluated These Anxiety Supplements
Our comprehensive review process involves a thorough analysis of each anxiety supplement based on several key factors:
Ingredient Quality and Efficacy
We evaluate each ingredient based on scientific research supporting its effectiveness for anxiety relief. We prioritize supplements that contain clinically-studied ingredients like Ashwagandha, L-Theanine, GABA, Magnesium, and other compounds with demonstrated anti-anxiety properties.
Safety Profile
We assess potential side effects, contraindications, and overall safety of each supplement. Products with clean formulations free from unnecessary fillers, artificial additives, and allergens receive higher ratings.
User Reviews and Satisfaction
Real-world effectiveness matters, so we analyze thousands of verified user reviews to understand how each supplement performs for actual customers dealing with anxiety symptoms.
Value for Money
We compare pricing against ingredient quality, dosage, and effectiveness to determine which supplements offer the best value, not just the lowest price.
Manufacturing Standards
We prioritize supplements manufactured in FDA-registered facilities following Good Manufacturing Practices (GMP), with third-party testing for purity and potency.
Our Research Team
Our reviews are conducted by a team of mental health specialists, nutritionists, and researchers with expertise in anxiety management and supplement formulation. All our content is medically reviewed to ensure accuracy and adherence to the latest scientific understanding of anxiety supplements.
Frequently Asked Questions
Common questions about anxiety supplements and their use.
How long do anxiety supplements take to work?
Most anxiety supplements require consistent use over time to achieve optimal results. While some people may notice mild effects within a few days, the full benefits typically develop over 2-6 weeks of regular use. Natural supplements work by gradually supporting your body's stress response systems rather than providing immediate relief like prescription medications.
Are anxiety supplements safe?
Most anxiety supplements containing natural ingredients are generally safe for healthy adults when taken as directed. However, even natural supplements can cause side effects or interact with medications. It's important to consult with a healthcare provider before starting any supplement, especially if you have existing health conditions, are pregnant or nursing, or are taking prescription medications.
Can I take anxiety supplements with my medication?
Some anxiety supplements may interact with prescription medications, particularly antidepressants, anti-anxiety medications, sedatives, or blood thinners. Always consult with your healthcare provider before combining supplements with prescription medications to avoid potential interactions that could reduce medication effectiveness or increase side effects.
What ingredients should I look for in anxiety supplements?
Research-backed ingredients for anxiety relief include Ashwagandha, L-Theanine, GABA, Magnesium, Rhodiola Rosea, Valerian Root, Lemon Balm, and 5-HTP. The best supplements typically contain a combination of these ingredients in clinically effective dosages. Look for products that clearly disclose the amount of each active ingredient.
Can anxiety supplements replace therapy or medication?
Anxiety supplements are best viewed as complementary approaches rather than replacements for professional treatment. For mild anxiety, supplements may provide sufficient support when combined with lifestyle changes. For moderate to severe anxiety, supplements work best as part of a comprehensive treatment plan that may include therapy, medication, stress management techniques, and lifestyle modifications.
Final Thoughts on Choosing the Right Anxiety Supplement
Finding the right anxiety supplement is a personal journey that depends on your specific symptoms, body chemistry, and health needs. The supplements featured in our review represent the best options available in 2025, based on ingredient quality, effectiveness, safety, and value.
Remember that supplements work best as part of a holistic approach to anxiety management. Consider combining supplement use with stress management techniques, regular exercise, adequate sleep, and a balanced diet for optimal results.
If you're dealing with severe anxiety symptoms, please consult with a healthcare provider before relying solely on supplements. A mental health professional can help determine the most appropriate treatment approach for your situation.
We hope this guide helps you make an informed decision about which anxiety supplement might work best for your needs. For more detailed information about any specific product, click through to our individual reviews.
Disclaimer
The information provided in this review is intended for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider before starting any supplement regimen, especially if you have existing health conditions or are taking medications.
This page contains affiliate links, and we may receive a commission for purchases made through these links at no additional cost to you. This helps support our research and testing so we can continue to provide reliable information.
Last updated: May 2025